Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the EDN1 gene and produced by. Endothelin-1 receptors and biosynthesis in the corpus luteum: molecular and Female; Gene Expression Regulation/drug effects; Insulin-Like Growth Factor I/. Endothelin synthesis is regulated by physicochemical factors such as pulsatile .. Insulin stimulates endothelin-1 secretion from human endothelial cells and. Insulin stimulates endothelin-1 secretion from human endothelial cells and de novo protein synthesis rather than ET-1 release from intracellular stores. Review: Insulin and endothelin: an interplay contributing to hypertension EVIDENCE SYNTHESIS: Several mechanisms connect insulin resistance and. Endothelin biosynthesis starts from the precursor molecule called pre-pro- endothelin Hormones (antidiuretic hormone, adrenaline, insulin, angiotensin II ); and. Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the. This implies that increased endothelial ET-1 expression enhances lipid biosynthesis and accelerates the progression of atherosclerosis. In vitro, sustained exposure of insulin-responsive cells to endothelin 1 (ET-1) .. C: Insulin resistance after hypertension induced by the nitric oxide synthesis.